Publications

Chuang P.-T., Cheng H.-J., Lin S.-J., Jan K.-M., Lee M.-M., Chien S. 1990. Macromolecular transport across surface arterial and venous endothelium in rats. Studies with Evans blue-albumin and horseradish peroxidase.  Arteriosclerosis 10(2):188-97. abstract pdf pubmed Arteriosclerosis

Hariharan I.K., Chuang P.-T., Rubin G.M. 1991. Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster.  Proc. Natl. Acad. Sci. USA 88(24):11266-70. abstract pdf pubmed Proc Natl Acad Sci USA

Chuang P.-T., Albertson D.G., Meyer B.J. 1994. DPY-27: A Chromosome condensation protein homolog that regulate C. elegans dosage compensation through association with the X chromosome.  Cell 79(3):459-74. abstract pdf pubmed Cell

McMahon A.P.; Chuang P.-T. 1996. Hedgehogs in the clinic.  Nat Med 2(12):1308-10. abstract pdf pubmed Nat Med

Chuang P.-T., Lieb J.D., Meyer B.J. 1996. Sex-specific assembly of a dosage compensation complex on the nematode X chromosome.  Science 274(5293):1736-9. abstract pdf pubmed Science

Yang Y., Drossopoulou G., Chuang P.-T., Duprez D., Marti E., Bumcrot D., Vargesson N., Clarke J., Niswander L., McMahon A., Tickle C. 1997. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.  Development 124(21):4393-404. abstract pdf pubmed Development

Lieb J.D., Albrecht M.R., Chuang P.-T., Meyer B.J. 1998. MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation.  Cell 92(2):265-77. abstract pdf pubmed Cell

Chuang P.-T., McMahon A.P. 1999. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.  Nature 397(6720):617-21. abstract pdf pubmed Nature

Chuang P.-T.; Kornberg T.B. 2000. On the range of Hedgehog signaling. Curr Opin Genet Dev 10(5):515-22. abstract pdf pubmed Curr Opin Genet Dev

Huo L., Roessler E., Dutra A., Chuang P.-T., McMahon A.P., Muenke M. 2000. Determination of the chromosomal location and genomic structure of the Hedgehog-Interacting protein gene and analysis of its role in holoprosencephaly.  Gene Funct. Dis 3-4:119-127. abstract pdf Gene Funct. Dis

Treier M., O'Connell S., Gleiberman A., Price J., Szeto D.P., Burgess R., Chuang P.-T., McMahon A.P., Rosenfeld M.G. 2001. Hedgehog signaling is required for pituitary gland development.  Development 128(3):377-86. abstract pdf pubmed Development

Bonifas J.M., Pennypacker S., Chuang P.-T., McMahon A.P., Williams M., Rosenthal A., De Sauvage F.J., Epstein E.H. Jr. 2001. Activation of expression of hedgehog target genes in basal cell carcinomas.  J Invest Dermatol 116(5):739-42. abstract pdf pubmed J Invest Dermatol

Kawakami T., Kawcak T., Li Y.-J., Zhang W., Hu Y., Chuang P.-T. 2002. Mouse dispatched mutants fail to distribute Hedgehog proteins and are defective in Hedgehog signaling.  Development 129(24):5753-65. abstract pdf pubmed Development

Stryke D., Kawamoto M., Huang C.C., Johns S.J., King L.A., Harper C.A., Meng E.C., Lee R.E., Yee A., L'Italien L., Chuang P.-T., Young S.G., Skarnes W.C., Babbitt P.C., Ferrin T.E. 2003. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.  Nucleic Acids Res 31(1):278-81. abstract pdf pubmed Nucleic Acids Res

Chuang P.-T.; McMahon A.P. 2003. Branching morphogenesis of the lung: new molecular insights into an old problem.  Trends Cell Biol 13(2):86-91. abstract pdf pubmed Trends Cell Biol

Chuang P.-T.*, Kawcak T., McMahon A.P. 2003. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding Protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung.  Genes Dev 17(3):342-7.  (*co-corresponding author) abstract pdf pubmed Genes Dev

Kawahira H., Ma N.H., Tzanakakis E.S., McMahon A.P., Chuang P.-T., Hebrok M. 2003. Combined activities of hedgehog signaling inhibitors regulate pancreas development.  Development 130(20):4871-9. abstract pdf pubmed Development

Vogt A., Chuang P.-T., Hebert J., Hwang J., Lu Y., Kopelovich L., Athar M., Bickers D.R., Epstein E.H. Jr. 2004. Immunoprevention of basal cell carcinoma with recombinant Hedgehog-interacting protein.  J Exp Med 199(6):753-61. abstract pdf pubmed J Exp Med

Chen M.-H., Li Y.-J., Kawakami T., Xu S.-M., Chuang P.-T. 2004. Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.  Genes Dev 18(6):641-59. abstract pdf pubmed Genes Dev

Yang S.H., Shrivastav A., Kosinski C., Sharma R.K., Chen M.-H., Berthiaume L.G., Peters L.L., Chuang P.-T., Young S.G., Bergo M.O. 2005. N-Myristoyltransferase I is essential in early mouse development.  J Biol Chem. 180(19):18990-5. abstract pdf pubmed J Biol Chem

Chen M.-H., Gao N., Kawakami T., Chuang P.-T. 2005. Mice deficient in the Fused homolog do not exhibit phenotypes indicative of perturbed Hedgehog signaling during embryonic development.  Mol Cell Biol 25(16):7042-53. abstract pdf pubmed Mol Cell Biol

Hu M.C., Mo R., Bhella S., Wilson, C., Chuang P.-T., Hui C.C., Rosenblum N.D. 2006. GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133(3):569-78. abstract pdf pubmed Development

Wilson C.W., Chuang P.-T. 2006. New "Hogs" in Hedgehog transport and signal reception.  Cell 125(3):435-8. abstract pdf pubmed Cell

Ochi H., Pearson B.J., Chuang P.-T., Hammerschmidt M, Westerfield M. 2006. Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.  Dev Biol 297(1):127-40. abstract pdf pubmed Dev Biol

Mak K.K., Chen M.-H., Day T.F., Chuang P.-T., Yang Y. 2006. Wnt/ß-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation.  Development 133(18):3695-707. abstract pdf pubmed Development

Gerber A.N., Wilson C.W, Li Y.-J., Chuang P.-T. 2007. The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation. Oncogene 26:1122-1136. abstract pdf pubmed Oncogene

Chen M.-H., Wilson C.W., Chuang P.-T.. 2007. SnapShot: hedgehog signaling pathway. Cell 130(2):386. abstract pdf pubmed Cell

Corbit K.C., Shyer A.E., Dowdle W.E., Gaulden J., Singla V., Chen M.-H., Chuang P.-T., Reiter J.F. 2008 Kif3a constrains beta-catenin-dependent Wnt signaling through dual ciliary and non-ciliary mechanisms.  Nat Cell Biol 10(1):70-6 [Erratum in Nat Cell Biol. 2008 Apr;10(4):497]. abstract pdf pubmed Nat Cell Biol

Mak K.K., Kronenberg H.M., Chuang P.-T., Mackem S., Yang Y. 2008. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.  Development 135(11):1947-56. abstract pdf pubmed Development

Mak K.K., Bi Y., Wan C., Chuang P.-T., Clemens T., Young M., Yang Y. 2008. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.  Dev Cell 14(5):674-88. abstract pdf pubmed Dev Cell