Cardiovascular Research Institute

Record List

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Name		Research Interest
Kaveh Ashrafi Assistant Professor CVRI Investigator		Genetics of fat regulation and neurobiology of feeding behavior

Harold S. Bernstein Professor in Residence, Pediatrics CVRI Investigator		Stem cells, cardiac muscle, skeletal muscle, cell cycle regulation

Brian L Black Professor CVRI Investigator		Cardiac and skeletal muscle development, differentiation, and function

Paul D Blanc Division Chief CVRI Investigator		Epidemiology of occupational lung disease, Asthma outcomes and Occupational toxicology

Elias H Botvinick Professor In Residence		Nuclear medicine, nuclear cardiology, PET/CT, MRI, CT, cardiac cardiology, echocardiology, nuclear magnetic resonance, cardiovascular imaging, stress testimg, heart, myocardial perfusion, scintigraphy, coronary, sychrony, sychronization

Homer A Boushey Prof & Chief CVRI Investigator		Bronchial hyperreactivity in asthma. Effects of viral infection on airway function. Regulation of airway mucous secretion and vascular permeability.

V Courtney Broaddus Professor CVRI Investigator		Role of apoptosis in asbestos-induced malignancy. Molecular interaction of asbestos fibers with mesothelial cells, specifically with regard to the role of cell surface adhesion receptors.

Frances M Brodsky Professor CVRI Investigator		REGULATION AND FUNCTION OF CLATHRIN-MEDIATED MEMBRANE TRAFFIC

James K Brown Assoc Prof In Rsdn & Dir CVRI Investigator		Protease signaling

Benoit G Bruneau Associate Professor CVRI Investigator		Heart development, congenital heart disease, chromatin, embryogenesis, transcription

George H Caughey Professor In Residence CVRI Investigator		Regulation of lung and airway function by mast cell, leukocyte and epithelial proteases

Harold A Chapman Professor CVRI Investigator		Antigen presentation by MHC class II molecules important to immunity and autoimmunity and extracellular matrix remodeling important to cell migration and tissue repair

Israel F Charo Professor In-Residence CVRI Investigator		Structure and Function of Chemokine Receptors

Kanu Chatterjee Professor		Diagnosing and managing coronary artery disease, heart failure and pulmonary hypertension.

Pao-Tien Chuang Assoc Professor In Residence CVRI Investigator		Cell-cell signaling during mammalian development and in postnatal physiology

Ronald I Clyman Prof In Rsdn Ped & CVRI CVRI Investigator		Cardiology, Cell Biology, Developmental Biology, Neonatology, Neonatal Cardiology

Bruce R Conklin Professor In Residence CVRI Investigator		Engineering Hormone Signaling Pathways In Vivo

Michael S Conte Chief, Vascular Surgery CVRI Investigator		Aortic reconstruction, carotid artery disease, lower extremity arterial occlusive disease, diabetic vascular disease

Shaun R Coughlin Professor CVRI Investigator		Signaling mechanisms in cardiovascular biology and disease, thrombin signaling

Rik M Derynck Professor CVRI Investigator		Transmembrane TGF-a and TGF-b receptor signaling in cell proliferation and differentiation.

Leland G Dobbs Adjunct Professor CVRI Investigator		Pulmonary alveolar epithelial development and response to injury, development of biomarkers for the measurement of lung injury

Mark D Eisner Assoc Professor In Residence CVRI Investigator		Epidemiology and health outcomes of obstructive lung disease Key words: asthma, COPD, epidemiology, indoor air pollution, environmental tobacco smoke, secondhand smoke, passive smoking, disability, severe asthma, health outcomes

Joanne N Engel Prof In Residence CVRI Investigator		Bacterial Pathogen-Host Cell Interactions

David J Erle Professor of Medicine In Resid CVRI Investigator		Asthma, allergy and inflammation; functional genomics

John Vincent Fahy Professor In Residence CVRI Investigator		Mechanism oriented studies of airway disease in human subjects

Robert V Farese Professor In Residence CVRI Investigator		Cell Biology of Energy Metabolism

Christopher J Fielding Professor CVRI Investigator		Cholesterol, high density lipoprotein (HDL), caveolae, signaling, lipid-binding, atherosclerosis, cholesterol-binding proteins, plasma membrane

Jeffrey R Fineman Professor in Residence CVRI Investigator		Endothelial regulation of the pulmonary circulation during normal development and during the development of pediatric pulmonary hypertension disorders. Endothelial dysfunction in pediatric pulmonary hypertension

David G Gardner Professor in Residence CVRI Investigator		Cardiovascular endocrinology, natriuretic peptides, natriuretic peptide receptors, vitamin D, nuclear hormone receptors, growth and hypertrophy in cardiovascular system and kidney, obesity-related cardiomyopathy.

Zev Jordan Gartner Acting Assistant Professor CVRI Investigator

Stanton A Glantz Professor of Medicine CVRI Investigator		Mechanics of cardiac function (experimental and theoretical); environmental tobacco smoke and tobacco control policy

Warren M Gold Professor CVRI Investigator		Pulmonary physiology, exercise physiology, pulmonary vascular obstruction, early diagnosis, dyspnea, asthma, COPD, diffusing capacity.

Michael Gropper Professor In Residence CVRI Investigator		Transfusion related acute lung injury, acute respiratory failure, acute respiratory distress syndrome, sepsis, ventilator associated pneumonia, resuscitation, mechanical ventilation, critical care outcomes

William Grossman Division Chief CVRI Investigator		Diastolic function of the left ventricle

Samuel Hawgood Chair CVRI Investigator		Structure and function of surfactant apoproteins

Arthur C Hill Prof of Clinical Surgery CVRI Investigator		Vascular biology, biomimetics, and New Technology in Cardiovascular Surgery.

Julien I Hoffman Professor Emeritus CVRI Investigator		Pathophysiology of myocardial ischemia

Holly A Ingraham Professor CVRI Investigator

Lily Y Jan Professor CVRI Investigator		Studies of potassium channels

David J Julius Chair and Professor CVRI Investigator

Yuet W Kan Professor CVRI Investigator		The mechanisms of globin production and exploring novel ways of inserting genes into mammalian cells; investigating newer approaches for fetal diagnosis of genetic disorders

John P Kane Prof CVRI Investigator		Structure and function of lipoproteins; genetic determinants of arteriosclerosis

Joel S Karliner Prof of Medicine Emeritus CVRI Investigator		Cardioprotection

Thomas B Kornberg Professor & Vice Chair CVRI Investigator		Developmental regulation

Theodore W Kurtz Prof in Res & Vice Chair CVRI Investigator		Molecular Genetics of Complex Disease, Genetic Models of Hypertension and the Metabolic Syndrome, Transcription Modulating Drugs

Pui-Yan Kwok Professor In Residence CVRI Investigator		Genetic analysis of complex traits, DNA technology development

Stephen C Lazarus Professor of Clinical Medicine CVRI Investigator		Role of inflammation in asthma and COPD, mucus hypersecretion.

Randall J Lee Prof of Clin Med CVRI Investigator		Arrhythmias, radiofrequency catheter ablation, implantable cardioverter/defibrillators, genetics, gene therapy, tissue engineering, stem cells, cell transplantation, biopolymers, antibodies, myocardial reconstruction/regeneration

Wendell A Lim Professor CVRI Investigator		Signal transduction, synthetic biology, systems biology, structural biology, protein-protein interactions, cell motility, MAP kinase cascades, GTPase pathways

Robert W Mahley Director CVRI Investigator		I. Plasma lipoprotein metabolism • Hepatic and intestinal origin of plasma lipoproteins; • Apolipoprotein structure and function, especially apolipoprotein (apo) E and apoB; • Characterization of cell surface receptors for lipoproteins; • Role of the liver in cholesterol homeostasis. II. Relationship of plasma lipoproteins to the development and progression of atherosclerosis • Role of diet in progression of coronary artery heart disease; • Effect of apoE production in the artery wall on inhibition of atherogenesis. III. Role of apoE in the nervous system • Effect on peripheral nerve injury and repair; • Role in the pathogenesis of Alzheimer’s disease; • Effect on neuronal cytoskeleton. IV. Turkish Heart Study • Director of epidemiological study to determine the risk factors responsible for coronary artery disease in Turkey; • Characterization of genetic polymorphisms responsible for low HDL-C levels and metabolic syndrome in Turks; • Co-director of physician continuing education program for Turkish doctors and medical students in the area of cardiovascular disease.

Mary J. Malloy Senate Emeritus CVRI Emeritus Investigator		Molecular mechanisms in lipoprotein metabolism; genetic basis of metabolic disorders of lipoproteins and of arteriosclerosis

Michael J Mann CVRI Investigator		1. Molecular/cellular biology and molecular genetics of atherosclerosis and heart failure. 2. Development of hybrid surgical and molecular/cellular therapies for heart disease. 3. Stem and progenitor cell transplantation for cardiovascular regeneration. 4. Cardiovascular tissue engineering. 5. Reduction to clinical practice of current methods in genetic, molecular and cellular disease intervention. 6. Novel targeted molecular therapies for lung cancer. 7. Molecular profiling of cancers for personalized medicine. 8. Development of novel methods of in vivo/ex vivo gene therapy and gene transfer. 9. Novel approaches to therapeutic neovascularization for coronary and peripheral ischemic disease. 10. Cardiovascular cell cycle biology. 11. Myocardial gene therapy.

Gail R Martin Professor CVRI Investigator		Function of the FGF family in early mammalian development; establishment of the vertebrate body plan during gastrulation

Michael A Matthay Professor In Residence CVRI Investigator		Alveolar epithelial transport under normal and pathologic conditions. Resolution of pulmonary edema Mechanisms of Acute Lung Injury

Donald M Mcdonald Professor CVRI Investigator		Angiogenesis; cancer; chronic inflammation; endothelial cells; vascular remodeling

Takashi Mikawa Professor In Residence, Camilla and George D. Smith Distinguished Professor in Science and Medicine CVRI Investigator		Morphogenesis, development, body axis, patterning, cell-to-cell communication, cell architecture, cell fate diversification, cardiovascular system, cardiac conduction system, central nervous system, haemodynamics, growth factor signaling.

Daniel L Minor Associate Professor CVRI Investigator		Membrane proteins; potassium channels, calcium channels

Keith E Mostov Professor CVRI Investigator		Polarized epithelial membrane traffic and epithelial morphogenesis.

Jay A Nadel Professor CVRI Investigator		Signaling mechanisms in airway epithelium

Jeffrey E Olgin Professor In Residence CVRI Investigator		Cardiac Electrophysiology, Arrhythmias, Mechanisms, Remodeling, Cardiac Fibrosis, Atrial Fibrillation, Cardiac Ablation, Mouse models, animal models, mouse electrophysiology, optical mapping, atrial fibrillation ablation, clinical trials.

David Pearce Professor of Medicine CVRI Investigator		Epithelial biology as it relates to cardiovasculare function: hypertension, fluid and electrolyte regulation.

Jean-Francois Pittet Professor In Residence CVRI Investigator		Molecular mechanisms of acute lung injury; molecular mechanisms of coagulation derangements after severe trauma.

Rita F Redberg Professor CVRI Investigator

Jeremy F. Reiter Asst Professor in Residence CVRI Investigator		Signaling, primary cilium, stem cell, Hedgehog, Wnt

Steven D Rosen Professor CVRI Investigator		Sulfated Sugars in Biological Processes

David H Rowitch Professor CVRI Investigator		Developmental biology, neural tube, CNS cell cycle control and tumorigenesis, cell fate specification, gliogenesis, oligodendrocyte differentiation and myelination, Sonic Hedgehog signaling, transcription factors, Olig bHLH proteins, multiple sclerosis, cerebral palsy, brain cancer.

Melvin M Scheinman Professor		Mechanisms of cardiac arrhythmias. Cardiac electrophysiology. Catheter ablation of arrhythmogenic foci.

Nelson B Schiller Professor of Cardiology CVRI Investigator		Dr. Schiller specializes in the use of echocardiography in the diagnosis and treatment of heart disease. His research interests center around the quantitation of left ventricular function by quantitative two-dimensional echocardiography and Doppler.

Robin M. Shaw Asst Professor In Residence CVRI Investigator		Cardiac Electrophysiology, Ion Channels, Arrhythmia, Sudden Cardiac Death, Heart Failure

Dean Sheppard Professor In Residence CVRI Investigator		In vivo function of integrins and molecular basis of lung diseases

Kevan M Shokat Professor CVRI Investigator		DESIGN OF DRUGS TO TREAT CARDIOVASCULAR DISEASE, CANCER, AND AUTOIMMUNE DISEASES.

Paul C Simpson Prof In Rsdn CVRI Investigator		Molecular & cellular mechanisms of myocardial hypertrophy and heart failure Adrenergic receptors, signaling, and drug development

Matthew L Springer Associate Professor In Residence CVRI Investigator		Angiogenesis, VEGF, stem cells, progenitor cells, gene therapy, heart failure, myocardial infarction, coronary artery disease, cardiac regeneration, peripheral artery disease, vascular injury, nitric oxide, flavanols, skeletal muscle myoblasts, secondhand smoke

Deepak Srivastava Director and Professor CVRI Investigator		Developmental biology, pediatric cardiology, congenital heart defects, organogenesis, human genetics, stem cells, cardiac repair

Didier Y. R. Stainier Professor CVRI Investigator		Vertebrate organ formation/cardiovascular development/endoderm, liver, pancreas and gut development and regeneration/stem cell differentiation/lipid transport and metabolism

David F Teitel Prof In Res CVRI Investigator		Pediatric cardiology, developmental cardiovascular physiology, cardiac mechanics, pediatric interventional cardiac catheterization, computer technology in cardiology, heart center administration, medical education, digital technology in learning, bioinformatics.

Mark E Von Zastrow Professor CVRI Investigator		Subcellular organization and dynamics of receptor-mediated signaling systems in eukaryotic cells.

Rong Wang Associate Professor in Res CVRI Investigator		Arteriogenesis, Arterial Venous Hierarchy, Arterial Venous Differentiation, Arteriovenous Malformations, Hemodynamics, Biomechanics, Vessel Graft, Collateral Vessel Formation, Vascular Disease, Vascular Imaging, Neovascularization, Angiogenesis Factor, Angiogenesis Inhibitors, Vascular Developmental, Vascular Physiology, Critical Limb Ischemia, Gene Expression Regulation, Tumor Angiogenesis, Hepatocellular Carcinoma, Breast Cancer, Notch, EphrinB2, Vascular Progenitor and Stem Cells, Mouse Genetics, Modeling Vascular Disease, Cell Biology, Molecular Pathogenesis of Vascular Diseases, Vessel Dilation, Microcirculation.

Orion D Weiner Asst Professor In Residence CVRI Investigator		Cell polarity, chemotaxis, actin cytoskeleton, cell signaling, cell migration, microscopy, biochemistry, neutrophils, systems biology, self-organization, inflammation, Rac, PI3Kinase, WAVE complex.

Arthur Weiss Chief of Rheumatology CVRI Investigator		Cell Surface Molecules and Molecular Events Involved in Lymphocyte Activation

Ethan J Weiss CVRI Associate Investigator		Coagulation, thrombosis, hemostasis, fibrinolysis, genetics, platelet, sexual dimorphism, sex hormone signaling.

Zena Werb Professor and Vice Chair CVRI Investigator		Extracellular communication in development and disease

Prescott G Woodruff Asst Professor In Residence CVRI Investigator		Genomics, Asthma, Chronic Obstructive Pulmonary Disease, Stereology, Epidemiology, Clinical Trials, Medical Education

Allison Wanting Xu Assistant Professor CVRI Investigator		Hypothalamic regulation of energy balance, obesity and type 2 diabetes

William L Young Professor/Vice Chair CVRI Investigator		Integrative physiology of the cerebral circulation with special reference to cerebral vascular malformations and occlusive cerebrovascular disease; angiogenesis-related aspects of cerebral hemorrhagic disease; clinical physiology of systemic and cerebral circulatory manipulation during neuroanesthetic management

Ann Zovein Assistant Professor CVRI Investigator		Vascular development, diversity of endothelial lineages, vascular contributions to stem cell niches including hematopoietic stem cell emergence

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CVRI Investigator Research Summaries