CVRI Scientists

Pao-Tien Chuang, M.D. , Ph.D.
Associate Professor of Biochemistry & Biophysics

Research Interests:
Cell-cell signaling during mammalian development and in postnatal physiology

Summary:
Our research aims to understand the molecular program that controls mammalian embryonic development, stem cell maintenance and cancer formation. Accumulating evidence indicates a common mechanism underlying these seemingly disparate processes. We have focused on the Hedgehog (Hh) pathway that plays a key role in many aspects of embryonic development and on dysregulation of Hh signaling that is associated with human birth defects and cancers. We use a combination of genetic, cell biological and biochemical approaches to reveal the molecular mechanisms by which Hh signaling controls various essential cellular processes. Our research will lead to a better understanding of mammalian embryonic development, provide insights into stem cell therapy and facilitate drug development for cancer treatment.