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CVRI Scientists
Ion channels and arrhythmias
Benoit G Bruneau, B.Sc., Ph.D.
Associate Professor
Research Interests:
Heart development, congenital heart disease, chromatin, embryogenesis, transcription
Summary:
Our laboratory studies the genes that direct a cell to become a heart cell, focusing on the machinery within each cell that turns genes on or off. Many of these factors are implicated in human congenital heart disease, and our studies also focus on understanding the basis of these diseases.
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Lily Y Jan, B.Sc., M.Sc., Ph.D.
Professor
Research Interests:
Studies of potassium channels
Summary:
Ion channels such as potassium channels and calcium-activated chloride channels are important for the function of the heart, lung, and vasculature. Starting with molecular characterizations of the channel proteins, we try to understand how these channels work and how their activities are regulated under various physiological conditions
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David J Julius, S.B., Ph.D.
Chair and Professor
Research Interests:
Summary:
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Randall J Lee, M.D., Ph.D.
Prof of Clin Med
Research Interests:
Arrhythmias, radiofrequency catheter ablation, implantable cardioverter/defibrillators, genetics, gene therapy, tissue engineering, stem cells, cell transplantation, biopolymers, antibodies, myocardial reconstruction/regeneration
Summary:
The research program integrates the disciplines of cell biology, bioengineering and cardiology. A tissue engineering approach is being used to investigate the potential application of cardiovascular reconstruction/regeneration. The use of stem cells and engineered polymer scaffolds are being investigated in heart attach models to determine their usefulness and safety in repairing damaged heart tissue.
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Takashi Mikawa, M.S., Ph.D.
Professor In Residence
Research Interests:
Morphogenesis, development, body axis, patterning, cell-to-cell communication, cell
architecture, cell fate diversification, cardiovascular system, cardiac conduction system,
central nervous system, haemodynamics, growth factor signaling.
Summary:
The establishment of extremely complicated structures and functions of our organ systems depends upon orchestrated differentiation and integration of multiple cell types. Our group focuses to explore a common developmental plan for
successful organogenesis, by investigating the mechanisms involved in the differentiation and patterning of the cardiovascular and central nervous systems.
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Daniel L Minor, Ph.D.
Associate Professor
Research Interests:
Membrane proteins; potassium channels, calcium channels
Summary:
Hearts, brains, muscles, and senses require electrical signals to function. We aim to understand the basic cellular components responsible for generating electrical activity. We focus on understanding the structure, function, and regulation of ion channels from a high-resolution viewpoint, understanding how channel mutations cause disease, and on developing new tools for controlling channel function.
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Jeffrey E Olgin, M.D.
Professor In Residence
Research Interests:
Cardiac Electrophysiology, Arrhythmias, Mechanisms, Remodeling, Cardiac Fibrosis, Atrial Fibrillation, Cardiac Ablation, Mouse models, animal models, mouse electrophysiology, optical mapping, atrial fibrillation ablation, clinical trials.
Summary:
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Robin M. Shaw, M.D., Ph.D.
Asst Professor In Residence
Research Interests:
Cardiac Electrophysiology, Ion Channels, Arrhythmia, Sudden Cardiac Death, Heart Failure
Summary:
The basic function of the heart is to work as a pump, circulating blood through the lungs and the rest of the body. Each heartbeat, millions of individual heart cells contract in synchrony for one overall large contraction. Improper contraction results in congestive heart failure and improper synchrony results in sudden cardiac death. My laboratory studies the basic biology of heart cell contraction and synchronous communication with a goal of developing novel treatment strategies of both heart failure and sudden cardiac death.
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