Ashrafi, Kaveh
Atabai, Kamran
Black, Brian L
Blanc, Paul D
Botvinick, Elias H
Boushey, Homer A
Broaddus, V Courtney
Brodsky, Frances M
Brown, James K
Bruneau, Benoit G
Caughey, George H
Chapman, Harold A
Charo, Israel F
Chawla, Ajay
Chuang, Pao-Tien
Clyman, Ronald I
Conklin, Bruce R
Conte, Michael S
Coughlin, Shaun R
DAngelo, Maximillano
Degrado, William F
Deo, Rahul C
Derynck, Rik M
Dobbs, Leland G
Engel, Joanne N
Erle, David J
Fahy, John Vincent
Farese, Robert V
Fineman, Jeffrey R
Ganz, Peter
Gardner, David G
Gartner, Zev Jordan
Glantz, Stanton A
Gold, Warren M
Grabe, Michael D
Gropper, Michael
Grossman, William
Gruenert, Dieter C
Hart, Daniel O
Hata, Akiko
Hawgood, Samuel
Hoffman, Julien I
Huang, Guo
Ingraham, Holly A
Jan, Lily Y
Julius, David J
Jura, Natalia Z
Kan, Yuet W
Kane, John P
Karliner, Joel S
Kornberg, Thomas B
Kurtz, Theodore W
Kwok, Pui-Yan
Lazarus, Stephen C
Lee, Randall J
Lim, Wendell A
Mahley, Robert W
Malloy, Mary J.
Mann, Michael J
Matthay, Michael A
Mcdonald, Donald M
Mikawa, Takashi
Minor, Daniel L
Mostov, Keith E
Oishi, Peter E
Olgin, Jeffrey E
Pearce, David
Redberg, Rita F
Reiter, Jeremy F.
Rock, Jason R.
Rowitch, David H
Scheinman, Melvin M
Schiller, Nelson B
Sheppard, Dean
Shokat, Kevan M
Shu, Xiaokun
Simpson, Paul C
Springer, Matthew L
Srivastava, Deepak
Teitel, David F
Von Zastrow, Mark E
Wang, Rong
Wang, Biao
Weiner, Orion D
Weiss, Arthur
Weiss, Ethan J
Werb, Zena
Woodruff, Prescott G
Xu, Allison Wanting
Yeghiazarians, Yerem
Zovein, Ann C

CVRI Scientists

Daniel O Hart, PhD
Asst Professor In Residence

Research Interests:
Zebrafish; development; transcription; stem cells

Summary:
The development of a multi-cellular organism from a single cell is a complex process that is regulated at many stages. One important level of regulation is the control of gene expression, that is, how and when genes are switched on or off to produce RNA and proteins. This process, transcriptional regulation, is critical for proper development. Disturbing this important step can have consequences for development and is often a hallmark of disease. It is therefore very important to understand the mechanisms underlying the transcriptional control of gene expression, and this is the broad aim of my lab.

We are particularly interested in understanding how general transcription factors can be used in specific ways to control genes. How they recognize where to bind in the genome, and what other factors (e.g. interacting proteins) may affect how they function to control development and differentiation.

CVRIHead