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| Ashrafi, Kaveh |
| Barber, Diane L |
| Bernstein, Harold S. |
| Black, Brian L |
| Blanc, Paul D |
| Boushey, Homer A |
| Broaddus, V Courtney |
| Brown, James K |
| Caughey, George H |
| Chapman, Harold A |
| Charo, Israel F |
| Chatterjee, Kanu |
| Chuang, Pao-Tien |
| Clyman, Ronald I |
| Conklin, Bruce R |
| Coughlin, Shaun R |
| Derynck, Rik M |
| Dobbs, Leland G |
| Eisner, Mark D |
| Engel, Joanne N |
| Erle, David J |
| Fahy, John Vincent |
| Farese, Robert V |
| Fielding, Christopher J |
| Fielding, Phoebe |
| Fineman, Jeffrey R |
| Glantz, Stanton A |
| Grossman, William |
| Hawgood, Samuel |
| Ingraham, Holly A |
| Jan, Lily Y |
| Kan, Yuet W |
| Kane, John P |
| Kornberg, Thomas B |
| Kurtz, Theodore W |
| Kwok, Pui-Yan |
| Lazarus, Stephen C |
| Malloy, Mary J. |
| Martin, Gail R |
| Matthay, Michael A |
| Mcdonald, Donald M |
| Mikawa, Takashi |
| Minor, Daniel L |
| Mostov, Keith E |
| Nadel, Jay A |
| Ordahl, Charles P |
| Pitas, Robert E |
| Reiter, Jeremy F. |
| Rosen, Steven D |
| Shaw, Robin M. |
| Sheppard, Dean |
| Simpson, Paul C |
| Stainier, Didier Y. R. |
| Wang, Rong |
| Weiner, Orion D |
| Weisgraber, Karl H |
| Weiss, Arthur |
| Weiss, Ethan J |
| Werb, Zena |
| Wiener-Kronish, Jeanine |
| Young, William L |
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CVRI Scientists
Stephen C. Lazarus, M.D.
Professor of Clinical Medicine
Research Interests:
Role of inflammation in asthma; mucus hypersecretion
Summary:
Dr. Lazarus is the Principal Investigator and Co-Investigator of the National Heart, Lung & Blood Institute's COPD Clinical Research Center at UCSF and Asthma Clinical Research Center at UCSF, respectively. Our research thus focuses on these two diseases.
Asthma affects 5-10% of the US population, and asthma mortality has increased for several decades. Our laboratory has helped to examine some of the issues that determine how and why different patients with asthma respond differently. We have examined some of the genetic factors that influence response to standard therapy and have found that a significant proportion of the general population has a specific genetic mutation that is associated with a poor response. We have found also that asthmatics who smoke do not respond to steroids as well as non-smokers. We are examining specific 'predictors' of response, which if successful will make it feasible to tailor therapy individually for each patient.
COPD (chronic obstructive pulmonary disease) is comprised of chronic bronchitis and emphysema and almost always occurs as a result of cigarette smoking. It is the 4th leading cause of death in the United States, and is expected to be the 3rd leading cause of death worldwide by 2020. Other than smoking cessation and oxygen therapy, no intervention has been shown to change the natural history of this disease. We are examining ways to prevent the exacerbations that contribute to progressive loss of lung function. In addition, based on observations made in our laboratory a number of years ago in studies of arachidonic acid metabolism in isolated mastocytoma cells, we are testing whether inhibition of a specific part of this metabolic pathway will speed the resolution of COPD exacerbations, and decrease the duration of hospitalizations for this disease.
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