CVRI Scientists

Charles P. Ordahl, Ph.D.
Professor of Anatomy

Research Interests:
Regulation of gene expression in early embryonic cardiac and skeletal muscle development

Summary:
Our lab is studying the epigenetic changes that direct embryonic cells to form muscle. Molecular studies have identified protein-DNA interactions that govern gene derepression during myoblast differentiation. Experimental embryological methods have allowed us to identify the place and timing of the decision process in vivo. Our current efforts are directed towards the control of the myoblast decision to differentiate through small molecule pharmacology.