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| Ashrafi, Kaveh |
| Barber, Diane L |
| Bernstein, Harold S. |
| Black, Brian L |
| Blanc, Paul D |
| Boushey, Homer A |
| Broaddus, V Courtney |
| Brown, James K |
| Caughey, George H |
| Chapman, Harold A |
| Charo, Israel F |
| Chatterjee, Kanu |
| Chuang, Pao-Tien |
| Clyman, Ronald I |
| Conklin, Bruce R |
| Coughlin, Shaun R |
| Derynck, Rik M |
| Dobbs, Leland G |
| Eisner, Mark D |
| Engel, Joanne N |
| Erle, David J |
| Fahy, John Vincent |
| Farese, Robert V |
| Fielding, Christopher J |
| Fielding, Phoebe |
| Fineman, Jeffrey R |
| Glantz, Stanton A |
| Grossman, William |
| Hawgood, Samuel |
| Ingraham, Holly A |
| Jan, Lily Y |
| Kan, Yuet W |
| Kane, John P |
| Kornberg, Thomas B |
| Kurtz, Theodore W |
| Kwok, Pui-Yan |
| Lazarus, Stephen C |
| Malloy, Mary J. |
| Martin, Gail R |
| Matthay, Michael A |
| Mcdonald, Donald M |
| Mikawa, Takashi |
| Minor, Daniel L |
| Mostov, Keith E |
| Nadel, Jay A |
| Ordahl, Charles P |
| Pitas, Robert E |
| Reiter, Jeremy F. |
| Rosen, Steven D |
| Shaw, Robin M. |
| Sheppard, Dean |
| Simpson, Paul C |
| Stainier, Didier Y. R. |
| Wang, Rong |
| Weiner, Orion D |
| Weisgraber, Karl H |
| Weiss, Arthur |
| Weiss, Ethan J |
| Werb, Zena |
| Wiener-Kronish, Jeanine |
| Young, William L |
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CVRI Scientists
Didier Y. R. Stainier, Ph.D.
Professor of Biochemistry & Biophysics
Research Interests:
Cardiovascular form and function in zebrafish
Summary:
Our laboratory is interested in understanding mechanisms regulating the development and function of the vertebrate cardiovascular system. To this end, we use the zebrafish because of its embryological and genetic advantages. Specifically, we start by using forward genetics to identify critical regulators of cardiovascular form and function. With the genes in hand, we then start asking more specific questions regarding cell biological and biochemical mechanisms.
We have elected to study heart development in the zebrafish, Danio rerio, because it offers unique advantages as a vertebrate genetic system and is also ideal for embryological studies. The zebrafish heart is accessible for continued observation and manipulation at all stages of development and offers single cell resolution of its components. Through several genome-wide screens in zebrafish, we have identified a large number of mutations that affect heart formation and function.
We are currently using the tools of cellular and molecular biology, embryology, genetics and advanced microscopy to analyze some of these mutations and further our understanding of the cellular and molecular mechanisms underlying various processes including myocardial differentiation, heart tube formation, endocardial cushion development, endothelial cell differentiation, vasculogenesis, angiogenesis and cardiac function.
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