CVRI Scientists

Arthur Weiss, M.D., Ph.D.
Professor of Medicine and Chief, Rheumatology Division; UCSF Investigator, Howard Hughes Medical Institute

Research Interests:
Signal transduction; autoimmunity

Summary:
The response of T lymphocytes to antigen presents a unique opportunity to study how complex molecular interactions between cells can lead to cell differentiation and proliferation. We are interested in understanding how T and B cell receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses. We know that such receptors functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate gene expression. We are interested in understanding how the molecules in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmunity.