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The Minor Lab
 
 

Our Research

We run on electricity. Brains, muscles, hearts, and senses all require electrical signals to function properly. Our research aims to understand the basic components of excitable cells that are responsible for generating electrical activity. To this end, we focus on understanding the structure, function, and regulation of ion channels from a high-resolution viewpoint.

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  Publications   Minor Lab Life  
 

Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block Chatelain, F.C., Gazzarrini, S., Fujiwara, Y., Arrigoni, C., Domigan, C., Ferrara, G., Pantoja, C., Thiel, G., Moroni, A., Minor, Jr., D.L., PLoS ONE Vol 4 Issue 10 e7496 (2009)

Searching for interesting channels: pairing selection and molecular
evolution methods to study ion channel structure and function.
Minor, Jr., D.L. Molecular BioSystems, 5, 802–810 (2009)

Crystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Xu, Q., Minor, Jr., D.L. Protein Science 18:2100—2114 (2009)

Disruption of the IS6-AID Linker Affects Voltage-gated Calcium Channel Inactivation and Facilitation. Findeisen, F., Minor, Jr., D.L., The Journal of General Physiology 133 No. 3, 327-343 (2009)

A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms. Hammon, J., Palanivelu, D.V., Chen, J., Patel, C., Minor, Jr., D.L. Protein Science 18, 121-133 (2009)

Alanine-Scanning Mutagenesis Defines a Conserved Energetic Hotspot in the CaVα1 AID-CaVβ Interaction Site that Is Critical for Channel Modulation. Petegem, F.V., Duderstadt, K.E., Clark, K.A., Wang, M., Minor, Jr., D.L., Structure 16, 280-294 (2008)

Our research facility is located
at the UCSF Mission Bay Campus in San Francisco.

Learn more about UCSF by choosing a quicklink below:

Opportunities

Currently we have the following job opportunities available:

Postdoctoral Positions

Students interested in graduate
programs should visit:

UCSF Graduate Programs

Website Quicklinks

Minor Lab Publications
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University of California, San Francisco - Minor Lab | tel: 415.514.2551 | fax: 415.514.2550 | daniel.minor@ucsf.edu
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