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The Minor Lab
 
 

Our Research

We run on electricity. Brains, muscles, hearts, and senses all require electrical signals to function properly. Our research aims to understand the basic components of excitable cells that are responsible for generating electrical activity. To this end, we focus on understanding the structure, function, and regulation of ion channels from a high-resolution viewpoint.

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  Publications   Minor Lab Life  
 

Multiple modalities converge on a common gate to control K2P channel function. Sviatoslav N Bagriantsev, Remi Peyronnet, Kimberly A Clark, Eric Honore, Daniel L Minor Jr. The EMBO Journal 30, 3594–3606 (2011)


Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. David Shaya, Mohamed Kreir, Rebecca A. Robbins, Stephanie Wong, Justus Hammon, Andrea Brüggemann, and Daniel L. Minor, Jr. PNAS Proc Natl Acad Sci USA. Jul 26;108(30):12313-8. (2011)

Calmodulin overexpression does not alter Cav1.2 function or oligomerization state. Felix Findeisen, Alexandra Tolia, Ryan Arant, Eun Young Kim, Ehud Y. Isacoff and Daniel L. Minor, Jr. Channels 5:4, 320-324; (2011)

Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation. Findeisen, Felix, Minor, Jr., D.L., Channels 4:5, 1-16 (2010)

Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.Findeisen, F., Minor, Jr., D.L. Channels 4:6, 1-16, (2010)

Calmodulin interactions with CaV1 and CaV2 voltage-gated calcium channel IQ domains. Kim, E.Y., Findeisen, F., Minor, Jr., D.L. Handbook of Metalloproteins (2010)

Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Kohout, S., Bell, S.C., Liu, L., Xu, Q., Minor, Jr., D.L., Isacoff, E.Y. Nature Chemical Biology 6, 369-375 (2010)

Structural Basis for the Differential Effects of CaBP1 and Calmodulin on CaV1.2 Calcium-Dependent Inactivation. Findeisen, F., Minor, Jr., D.L. Structure 18, 1617–1631 (2010)

Multiple C-terminal tail Ca2+/ /CaMs regulate CaV1.2 function but do not mediate channel dimerization. Ki., E., Rumpf, C., Van Petegem, F., Arant, R.J., Findeisen, F., Cooley, E., Isacoff, E., Minor, Jr., D.L. The EMBO Journal, 29, 3924-3938 (2010)

Our research facility is located
at the UCSF Mission Bay Campus in San Francisco.

Learn more about UCSF by choosing a quicklink below:

Opportunities

Currently we have the following job opportunities available:

Postdoctoral Positions

Students interested in graduate
programs should visit:

UCSF Graduate Programs

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Minor Lab Publications
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University of California, San Francisco - Minor Lab | tel: 415.514.2551 | fax: 415.514.2550 | daniel.minor@ucsf.edu
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