About Us Research Interests Publications Structures Contact
The Minor Lab

Our Research

We run on electricity. Brains, muscles, hearts, and senses all require electrical signals to function properly. Our research aims to understand the basic components of excitable cells that are responsible for generating electrical activity. To this end, we focus on understanding the structure, function, and regulation of ion channels from a high-resolution viewpoint.

Learn more


  Publications   Minor Lab Life  

Bacterial voltage-gated sodium channels (BacNaVs) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart. Payandeh, J. and Minor, D.L., Jr. Journal of Molecular Biology 427 3-30 (2015) PMID: 25158094 PMCID: PMC4277928

Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K2P channels. Lolicato, M., Riegelhaupt, P.M., Arrigoni, C., Clark, K.A., Minor, D.L., Jr. Neuron 84 1198-1212 (2014) PMID: 25500157 PMCID: PMC4270892

Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries. Bagriantsev, S.N, Chatelain, F.C., Clark, K.A., Alagem, N., Reuveny, E., and Minor, D.L., Jr. ACS Chemical Neuroscience 5 812-822 (2014) PMID: 25028803 PMCID: PMC31476385

A high-throughput functional screen identifies small molecule regulators or temperature- and mechano-sensitive K2P channels. Bagriantsev, S. N., Ang, K.H., Gallardo-Godoy, A, Clark, K.A., Arkin, M.R., Renslo, A.R, and Minor, D.L., Jr. ACS Chemical Biology 8 1841-1851 (2013) PMID: 23738709PMCID: PMC3747594

Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels. Shaya, D., Findeisen, F., Abderemane-Ali, F., Arrigoni, C., Wong, S., Reddy Nurva, S., Loussouarn, G., and Minor, D.L., Jr. Journal of Molecular Biology 426 476-483 (2014) PMID: 24120938 PMCID: PMC3947372

Structure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M-current modulation.Xu, Q., Chang, A., Tolia, A., and Minor, D.L., Jr., Journal of Molecular Biology 425 378-394 (2013) PMID: 23178170 PMCID: PMC3540129

Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains. Bagriantsev, S., Clark, K.A., and Minor, D.L., Jr., The EMBO Journal 31 3297-3308 (2012) PMID: 22728824 PMCID: PMC3411076

A glutamate switch controls voltage-sensitive phosphatase function. Liu L., Kohout, S.C., Xu, Q., Müller, S., Kimberlin, C.R., Isacoff, E.Y. Minor, D.L., Jr., Nature Structural and Molecular Biology 19 633-641 (2012) PMID: 22562138 PMCID: PMC3529583


Our research facility is located
at the UCSF Mission Bay Campus in San Francisco.

Learn more about UCSF by choosing a quicklink below:


Currently we have the following job opportunities available:

Postdoctoral Positions

Students interested in graduate
programs should visit:

UCSF Graduate Programs

Website Quicklinks

Minor Lab Publications
Minor Lab Structures
Minor Lab People

University of California, San Francisco—Minor Lab | tel: 415.514.2551 | fax: 415.514.2550 | daniel.minor@ucsf.edu
Copyright © 2016, Regents of the University of California. All Rights Reserved. Site Map