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The Minor Lab
 
 

Our Research

We run on electricity. Brains, muscles, hearts, and senses all require electrical signals to function properly. Our research aims to understand the basic components of excitable cells that are responsible for generating electrical activity. To this end, we focus on understanding the structure, function, and regulation of ion channels from a high-resolution viewpoint.

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  Publications   Minor Lab Life  
 

Structure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M-current modulation.Xu, Q., Chang, A., Tolia, A., and Minor, D.L., Jr., Journal of Molecular Biology 425 378-394 (2013) PMID: 23178170 PMCID: PMC3540129

Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains. Bagriantsev, S., Clark, K.A., and Minor, D.L., Jr., The EMBO Journal 31 3297-3308 (2012) PMID: 22728824 PMCID: PMC3411076

A glutamate switch controls voltage-sensitive phosphatase function. Liu L., Kohout, S.C., Xu, Q., Müller, S., Kimberlin, C.R., Isacoff, E.Y. Minor, D.L., Jr., Nature Structural and Molecular Biology 19 633-641 (2012) PMID: 22562138 PMCID: PMC3529583

Multiple modalities converge on a common gate to control K2P channel function. Sviatoslav N Bagriantsev, Remi Peyronnet, Kimberly A Clark, Eric Honore, Daniel L Minor Jr. The EMBO Journal 30, 3594–3606 (2011)

 

Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. David Shaya, Mohamed Kreir, Rebecca A. Robbins, Stephanie Wong, Justus Hammon, Andrea Brüggemann, and Daniel L. Minor, Jr. PNAS Proc Natl Acad Sci USA. Jul 26;108(30):12313-8. (2011)

Calmodulin overexpression does not alter Cav1.2 function or oligomerization state. Felix Findeisen, Alexandra Tolia, Ryan Arant, Eun Young Kim, Ehud Y. Isacoff and Daniel L. Minor, Jr. Channels 5:4, 320-324; (2011)

Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation. Findeisen, Felix, Minor, Jr., D.L., Channels 4:5, 1-16 (2010)


Our research facility is located
at the UCSF Mission Bay Campus in San Francisco.

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Opportunities

Currently we have the following job opportunities available:

Postdoctoral Positions

Students interested in graduate
programs should visit:

UCSF Graduate Programs

Website Quicklinks

Minor Lab Publications
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University of California, San Francisco - Minor Lab | tel: 415.514.2551 | fax: 415.514.2550 | daniel.minor@ucsf.edu
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