University of Pennsylvania, B.A., Biochemistry and Biophysics, 1989

Massachusetts Institute of Technology, Ph.D., Chemistry, 1996

Established Investigator, American Heart Association 2007

McKnight Technological Innovations in Neuroscience Award 2004-2006

McKnight Scholar in Neurosciences 2001-2004

Rita Allen Scholar 2001-2004

March of Dimes, Basil O'Connor Scholar 2002-2004

Beckman Young Investigator 2002-2004

Alfred P. Sloan Research Fellow 2002-2004

Searle Scholar 2002-2004

Molecular structure and mechanism of ion channel action

Development of novel methods for ion channel regulation

Published in the Handbook of Cell Signaling, 2nd Edition, Chapter author: Daniel L. Minor, An Overview of Ion Channel Structure., Pages 201-208, Copyright Elsevier (2009)

Chatelain, F.C., Gazzarrini, S., Fujiwara, Y., Arrigoni, C., Domigan, C., Ferrara, G., Pantoja, C., Thiel, G., Moroni, A., Minor, Jr., D.L., Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block PLoS ONE Vol 4 Issue 10 e7496 (2009)

Minor, Jr., D.L., Searching for interesting channels: pairing selection and molecular
evolution methods to study ion channel structure and function. Molecular BioSystems, 5, 802–810 (2009)

Xu, Q., Minor, Jr., D.L., Crystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Protein Science 18:2100—2114 (2009)

Findeisen, F., Minor, Jr., D.L., Disruption of the IS6-AID Linker Affects Voltage-gated Calcium Channel Inactivation and Facilitation. The Journal of General Physiology 133 No. 3, 327-343 (2009)

Hammon, J., Palanivelu, D.V., Chen, J., Patel, C., Minor, Jr., D.L. A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms. Protein Science 18, 121-133 (2009)

Balss, J., Papatheodorou, P., Mehmel, M., Baumeister, D., Hertel, B., Delaroque, N., Chatelain, F.C., Minor, Jr., D.L., Van Etten, J.L., Rassow, J., Moroni, A., Thiel, G., Transmembrane domain length of viral K channels is a signal for mitochondria targeting. PNAS 34, 12313-12318 (2008)

Fujiwara, Y., Minor, Jr., D.L. X-ray Crystal Structure of a TRPM Assembly Domain Reveals an Antiparallel Four-stranded Coiled-coil. J. Mol. Biol. 383, 854-870 (2008).

Kim, E.Y., Rumpf, C.H., Fujiwara, Y., Cooley, E.S., Van Petegem, F., and Minor, Jr., D.L. Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure 16, 1455-1467 (2008).

Minor, Jr., D.L. and Kim P. S., Measurement of the beta-sheet forming propensities of amino acids. Nature 367 660-663 (1994).

Minor, Jr., D.L. and Kim P.S., Context is a major determinant of beta-sheet propensity. Nature 371 264-267 (1994).

Schumacher, T.N.M., Mayr, L.M., Minor, Jr., D.L., Milhollen, M.A., Burgess, M.W. and Kim, P.S., Identification of (D)-peptide ligands through Mirror-Image phage display. Science 271 1854-1857 (1996).

Minor, Jr., D.L. and Kim P.S., Context-dependent secondary structure formation of a designed protein sequence. Nature 380 730-734 (1996).

Minor, Jr., D.L., Masseling, S.J., Jan, Y.N. and Jan, L.Y., Transmembrane structure of an inwardly rectifying potassium channel. Cell 96 879-891 (1999).

Minor, Jr., D.L., Lin, Y.F, Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y. and Berger, J.M., The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102  657-670 (2000).

Mosavi, L. K., Minor, Jr., D.L., and Peng, Z.-y., Consensus-derived structural determinants of the ankyrin repeat motif. Proceedings of the National Academy of Sciences USA 99 16029-16034 (2002).

Walden, H., Podgorski, M.S., Huang, D.T., Miller, D.W., Howard, R.J., Minor, Jr., D.L., Holton, J.M., and Schulman, B.A., The structure of APPBP-1UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Molecular Cell 12 1427-1437 (2003).

Van Petegem, F., Clark, K.A., Chatelain, F.C., and Minor, Jr., D.L., Structure of a complex between a voltage gated calcium channel beta-subunit and an alpha-subunit domain. Nature 429 671-675 (2004)

Chatelain, F.C., Alagem, N., Xu, Q., Pancaroglu, R., Reuveny, E., and Minor, Jr., D.L., The pore helix dipole has a minor role in inward rectifier channel function. Neuron 47, 833-843 (2005).

Van Petegem, F., Chatelain, F.C., and Minor, Jr., D.L. Insights into voltage-gated calcium channel regulation from the structure of the Ca_V1.2 IQ domain-Ca²⁺/calmodulin complex. Nature Structural and Molecular Biology 12 1108-1115 (2005).

Michelsen, K., Mrowiec, T., Duderstadt, K.E., Frey, S., Minor, Jr., D.L., Mayer, M.P., Schwappach, B., A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Traffic 7 903-916 (2006).

Tsuruda, P., Julius, D., and Minor, Jr., D.L., Coiled coils direct assembly of a cold-activated TRP channel. Neuron 51 201-212 (2006).

Pioletti, M., Findeisen, F., Hura, G.L., and Minor, Jr., D.L., Three-dimensional structure of the KChIP/Kv4.3 T1 domain complex reveals a cross-shaped octamer. Nature Structural & Molecular Biology (2006).

Howard, R.J., Clark, K.A., Holton, J.M., and Minor, Jr., D.L., Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Neuron 53 663-675 (2007).

Petegem, F.V., Duderstadt, K.E., Clark, K.A., Wang, M., Minor, Jr., D.L., Alanine-Scanning Mutagenesis Defines a Conserved Energetic Hotspot in the Ca_Vα₁ AID-Ca_Vβ Interaction Site that Is Critical for Channel Modulation. Structure 16, 280-294 (2008).

Minor, Jr., D.L., Potassium Channels: life in the post-structural world. Current Opinion in Structural Biology 11  408-414 (2001).

Yi, B.A, Minor, Jr., D.L., Lin, Y.F., Jan, Y.N. and Jan, L.Y., Controlling potassium channel activities: Interplay between the membrane and intracellular factors. Proceedings of the National Academy of Sciences USA 98 11016-11023 (2001).

Minor, Jr., D.L., Overview: Function and three-dimensional structures of ion channels. Handbook of Cellular Signaling Eds. R. Bradshaw and E. Dennis, Academic Press, San Diego (2004).

Minor, Jr., D.L., Bend to open? Structure 13 1094-1095 (2005).

Minor, Jr., D.L., A sensitive channel family replete with sense and motion. Nature Structural & Molecular Biology 13 388-390 (2006).

Minor, Jr., D.L., Wanting contact: how to pick up a channel. Nature Chemical Biology 2 298-299 (2006).

Van Petegem, F. and Minor, Jr., D.L., The structural biology of voltage-gated calcium channel function and regulation. Biochemical Society Transactions Vol 34, part 5 (2006).

Minor, Jr., D.L., Puzzle plugged by pore plasticity. Molecular Cell 26 459-460 (2007).

Minor, Jr., D.L., The neurobiologist's guide to structural biology: A Primer on why macromolecular structure matters and how to evaluate macromolecular structural data. Neuron 54 511-533 (2007).