Covers & Press
Covers
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and relies on ‘toxin sponge’ proteins.
Abderemane-Ali, F., Rossen, N.D., Kobiela, M.E., Craig, R.A.II, Garrison, C.E., Chen, Z., O'Connell, L.A., Du Bois, J., Dumbacher, J.P., and Minor, D.L. Jr.
Journal of General Physiology 153:e202112872 (2021) PMID: 34351379 PMCID: PMC8348241
SARAF luminal domain structure reveals a novel domain-swapped β-sandwich fold important for SOCE modulation.
Kimberlin, C.R.,Meshcheriakova, A., Palty, R., Karbat, I., Reuveny, E., and Minor, D.L. Jr.
Journal of Molecular Biology 431 2869-2883 (2019) PMID:31082439 PMCID: PMC6599547
Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.
Shaya, D., Findeisen, F., Abderemane-Ali, F., Arrigoni, C., Wong, S., Reddy Nurva, S., Loussouarn, G., and Minor, D.L., Jr.
Journal of Molecular Biology 426 476-483 (2014) PMID: 24120938 PMCID: PMC3947372
Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.
Findeisen, Felix, Minor, Jr., D.L.
Channels 4:5, 1-16 (Dec 2010)
Alanine-Scanning Mutagenesis Defines a Conserved Energetic Hotspot in the CaVα1 AID-CaVβ Interaction Site that Is Critical for Channel Modulation.
Petegem, F.V., Duderstadt, K.E., Clark, K.A., Wang, M., Minor, Jr., D.L.
Structure 16, 280-294 (2008)
EMC chaperone-CaV structure reveals an ion channel assembly intermediate.
Chen, Z., Mondal, A., Abderemane-Ali, F., Jang, S., Niranjan, S., Montaño, J.L., Zaro, B.W., and Minor, D.L., Jr.
Nature 619 410-419 (2023)
Structural basis for CaVɑ 2δ:gabapentin binding.
Chen, Z., Mondal, A., and Minor, D.L., Jr.
Nature Structural and Molecular Biology 30 735-739 (2023)
» Nature Structural and Molecular Biology News & Views
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family.
Chen, Z., Zakrzewska, S., Hajare, H., Alvarez-Bullya, A., Abderemane-Ali, F., Bogan, M., Ramirez, D., O’Connell, L.A., Du Bois, J., and Minor, D.L., Jr.
Proceedings of the National Academy of Sciences, USA 119:e2210114119 (2022)
» Advanced Photon Source Science Highlight
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and relies on ‘toxin sponge’ proteins.
Abderemane-Ali, F., Rossen, N.D., Kobiela, M.E., Craig, R.A.II, Garrison, C.E., Chen, Z., O'Connell, L.A., Du Bois, J., Dumbacher, J.P., and Minor, D.L. Jr.
Journal of General Physiology 153:e202112872 (2021) PMID: 34351379 PMCID: PMC8348241
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins.
Yen, T.-J., Lolicato, M., Thomas-Tran, R., Du Bois, J.,
and Minor, D.L. Jr
Science Advances 5 eaax2650 (2019) PMID: 31223657 PMCID: PMC6584486
Interviews & Webinars
Cal Academy of Sciences:
‘Night School: Nature is Nurture’
Webinar presentation on poison birds and poison frogs with
Jack Dumbacher, Ph.D. (CAS), Fayal Abderemane-Ali, Ph.D. (UCSF), Dan Minor, Ph.D. (UCSF)
September 2, 2021
Can our relationship with nature foster human health? Join scientists as they share how studying nature—and protecting it—leads to a healthier planet and people.
View the webinar at:
https://youtu.be/GYTc7OhrXbY
Changing Channels
Interview with SBgrid consortium by Daniel Minor Jr.
Published September 27, 2019
Kissing a frog might not spark a fairy tale ending, but learning how frogs survive some of nature’s most deadly poisons has opened a new chapter in the laboratory of Daniel Minor Jr.
Read more at:
https://sbgrid.org/members/tale/changing-channels
SBGrid Weekly Webinar Series
K2P channel gating caught in the act: asymmetric pinching and dilation of a potassium channel selectivity filter by Daniel Minor
Watch Youtube video now at: https://www.youtube.com/watch?v=mOcawNNxY64&t=3s
