Asthma affects over 34 million Americans and over 300 million people worldwide. A quarter million people die each year from asthma around the world and asthma prevalence is on the rise. Asthma has increased by 75% since 1980, with incidence increasing by 160% in children.

Now, more than ever, research focused on understanding the mechanisms of asthma are needed to help guide the development of tailored treatments.

 

 

 

 

 

 

 

 

 

The Fahy Lab

Selected Recent Publications

  1. Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV; National Heart, Lung, and Blood Institute Severe Asthma Research Program. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016 Jul;4(7):574-84.
  2. Gordon ED, Locksley RM, Fahy JV. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 May 1;193(9):935-6.
  3. Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Yun Lim F, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV. FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection. PLoS Pathog. 2016 Apr 8;12(4):e1005555.
  4. Reber LL, Fahy JV. Mast cells in asthma: biomarker and therapeutic target. Eur Respir J. 2016 Apr;47(4):1040-2.
  5. Fahy JV. Asthma Was Talking, But We Weren't Listening. Missed or Ignored Signals That Have Slowed Treatment Progress. Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S78-82.
  6. Dunican EM, Fahy JV. The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations. Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S144-9.
  7. Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM, Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S, Fahy JV. Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Sci Transl Med. 2015 Feb 25;7(276):276ra27.
  8. Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV. Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma. Am J Respir Crit Care Med. 2014 Apr 15;189(8):1005-7.
  9. Houser J, Komarek J, Kostlanova N, Cioci G, Varrot A, Kerr SC, Lahmann M, Balloy V, Fahy JV, Chigard M, Imberty A, Wimmerova M. A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity. PLoS One. 2013 Dec 10.
  10. Peters MC, Mekonnen ZK, Yuan S, Bhakta NR, Woodruff PG, Fahy JV. Measures of gene expression in sputum cells can identify T(H)2-high and T(H)2-low subtypes of asthma. J Allergy Clin Immunol. 2013 Sep 24.
  11. Bhakta NR, Solberg OD, Nguyen CP, Nguyen CN, Arron JR, Fahy JV, Woodruff PG. A qPCR-based metric of Th2 airway inflammation in asthma. Clin Transl Allergy. 2013 Jul 17
  12. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA, Peters SP, Sheerar D, Shi L, Sutherland ER, Szefler SJ, Wechsler ME, Sorkness CA, Lemanske RF Jr; NHLBI Asthma Clinical Research Network Investigators. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013 Jan 1
  13. Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy JV, Woodruff PG, Harris JM, Arron JR; Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) Study Group. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012 Sep.
  14. Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, Stream AR, Fahy JV, Leung DY; Asthma Clinical Research Network. Cluster analysis of obesity and asthma phenotypes. PLoS One. 2012.
  15. Wong McGrath, K, Icitovic, N, Boushey, HA, Lazarus, SC, Sutherland, ER, Chinchilli, VM, Fahy, JV; Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. A Large Subgroup of Mild-to-Moderate Asthma is Persistently Noneosinophilic. Am J Respir Crit Care Med. 2012 Mar 15.

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Airway Clinical Research Center ∙ UCSF Moffitt Hospital, 13th Floor ∙ San Francisco, Ca 94143
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