University of California, San Francisco
CMP Department
Pubmed search for Natalia Jura publications

Jura, N., Shan, Y., Cao, X., Shaw, D.E., Kuriyan, J.

Proceedings of the National Academy of Sciences of the United States of America (2009); 106: 21608-21613

Structural analysis of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)

Jura, N., Endres, N.F., Engel, K., Deindl, S., Das, R., Lamers, M.H., Wemmer, E., Zhang X., Kuriyan, J.

Cell (2009); 137: 1293-307

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.

Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P. and Kuriyan, J. 

Nature (2007); 450: 741-4

Differential modification of Ras proteins by ubiquitination

Jura, N., Scotto-Lavino, E., Sobczyk, A., Bar-Sagi, D. 

Molecular Cell (2006); 21: 679-687

Mapping Cellular Routes of Ras – A Ubiquitin Trial.

Jura, N., Bar-Sagi, D.

Cell Cycle (2006); 5: 2744-2747

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen

Archer, H.*, Jura, N.*, Jacobson, M., Keller, J., Bar-Sagi, D. 

Gastroenterology (2006); 131: 1844-55  *) equal contribution

Chronic pancreatitis, pancreatic adenocarcinoma and the black box in between

Jura, N., Archer, H., Bar-Sagi, D.

Cell Research (2005); 15: 72-77

An ex vivo model for functional studies of myofibroblasts

Kilarski, W., Jura, N., Gerwins, P.

Laboratory Investigation (2005); 85: 643-654

Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis

Mezyk-Kopec, R., Bzowska, M., Potempa, J., Bzowska, M., Jura, N., Sroka, A., Black, R.A., Bereta, J.

Infection and Immunity (2005); 73: 1506-1514

Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells

Bzowska, M., Jura, N., Lassak, A., Black, R.A., Bereta, J.

European Journal of Biochemistry (2004); 271: 2808-2820

hSpry2 is targeted to the ubiquitin dependent proteasome pathway by c-Cbl

Hall, A.B.*, Jura, N.*, DaSilva, J., Jang, Y.J., Gong, D., Bar-Sagi, D.

Current Biology (2003); 13: 308-314. *) equal contribution.

Inactivation of Src family kinases inhibits angiogenesis in vivo: implications for a mechanism involving organization of the actin cytoskeleton

Asymmetric dimer between two kinase domains of the EGF receptor. By Kate Engel.

Jura, N., Zhang, X, Endres, NF., Seeliger, M., Shindler, T., Kuriyan, J.

Molecular Cell (2011); 42: 9-22

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms

Littlefield, P. and Jura, N.

Proceedings of the National Academy of Sciences of the United States of America (2013);

110: 15169-15170

EGFR lung cancer mutants get specialized

Fan Q.W., Cheng C. K., Gustafson W. C., Charron E., Zipper P., Wong R. A., Chen J., Lau J., Knobbe-Thomsen C., Weller M., Jura N., Reifenberger G., Shokat K. M., Weiss W. A.

Cancer Cell (2013); 24: 438-49

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in gliobalstoma
A robust methodology to subclassify pseudokinases based on their nucleotide binding properties.
Murphy J.M., Zhang Q., Young S.N., Reese M.L., Bailey F.P., Eyers P.A., Ungureanu D., Hammaren H., Silvennoinen O., Varghese L. N., Chen K., Tripaydonis A., Jura N., Fukuda K., Qin J., Nimchuk Z., Mudgett M. B., Elowe S., Gee C.L., Liu L., Daly R.J., Manning G., Babon J.J., Lucet I.S.
Biochem J (2014); 457: 323-34
Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Littlefield P., Liu L., Mysore V., Shan Y., Shaw D.E. and Jura N.
Science Signaling (2014); 7, ra114

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In the news:

The Juxtamembrane Region of EGFR Takes Center Stage
Stevan R. Hubbard, Cell Preview (2009); 137: 1181-1183

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Ras ubiquitination: Coupling spatial sorting and signal transmission
P. Rodriguez-Viciana, F. McCormick, Cancer Cell Preview (2006); 9: 243-244

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Split personalities: the agonistic antagonist Sprouty
Gerhard Christofori, Nature Cell Biology News & Views (2003); 5: 377-379
Inducing Sprouty degradation
Nicole LeBrasseur, J. of Cell Biology Research Roundup (2003); 160: 804

Kilarski, W.W., Jura, N., Gerwins, P.

Experimental Cell Research (2003); 291: 70-82

In the news:

Genetically defined models of chronic pancreatitis
M. Schmid and D. C. Whitcomb
Gastroenterology Editorial (2006); 131: 2012-2015
Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor.
Kovacs E., Das R., Wang Q., Collier T.S., Cantor A., Huang Y., Wong K., Mirza A., Barros T., Grob P., Jura N., Bose R. and Kuriyan J
Molecular and Cellular Biology (2015); 35: 3083-102

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Src defines a new pool of EGFR substrates.
Michael N. and Jura N.
Nature Structural and Molecular Biology (2015); 22: 945-7
Structural basis for the non-catalytic functions of protein kinases.
Kung J.E.. and Jura N.
Structure (2016); 24: 7-24
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EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms. van Lengerich, B., Agnew, C., Puchner, E., Huang, B., and Jura N.
Proceedings of the National Academy of Sciences of the United States of America (2017); 114:: E2836-E2845
Switching on BTK - One Domain at a Time
Agnew C. and Jura N.
Structure (2017); 25: 1469-1470
Feedback Regulation of RTK signaling in development
Neben, C.L., Lo, M., Jura N. and Klein O.D.
Development (2017); 1606: 30377-9
Regulation of Kinase Activity in Caenorhabditis elegans EGF Receptor, LET-23
Liu L., Thaker T.M., Freed D.M., Frazier N., Malhorta K., Lemmon M.A., and  Jura N. 
Structure (2018); 26: 270-281
Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras
Liang S.I., van Lengerich B., Eichel K., Cha M., Patterson D.M., Yoon T.Y., von Zastrow M., Jura N. and Gartner Z.J.
Cell Reports (2018); 22: 2593-2600
Activating HER3 mutations in breast cancer
Mishra R., Alanazi S., Yuan L., Solomon T., Thaker T.M., Jura N. and Garrett J.T
Oncotarget (2018); 9: 27773-27788
Actionable activating oncogenic ERBB2/HER2 transmembrane and juxtamembrane domain mutations
Bajaj K., Nguyen T.T., Jaiswal B.S., Chaudhuri S., Thaker T.M. Senger K., Kljavin N.M., Stawiski E.W., Durinck S., Gupta R., Trabucco S., Sokolo E., Phakle S., Mravic M., DeGrdao W.F., Bueon R., Prabash K., Jura N. and Seshagiri S.
Cancer Cell (2018); in press

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