Publications

Jura

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UC

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University of California, San Franciscohttp://www.ucsf.edu/
CVRIhttp://cvri.ucsf.edu/
CMP Departmenthttp://cmp.ucsf.edu/
 
Pubmed search for Natalia Jura publicationshttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Search&db=pubmed&term=%28Jura%20N%5BAuthor%5D%29

Jura, N., Shan, Y., Cao, X., Shaw, D.E., Kuriyan, J.

Proceedings of the National Academy of Sciences of the United States of America (2009); 106: 21608-21613

Structural analysis of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)
http://www.ncbi.nlm.nih.gov/pubmed/20007378

Jura, N., Endres, N.F., Engel, K., Deindl, S., Das, R., Lamers, M.H., Wemmer, E., Zhang X., Kuriyan, J.

Cell (2009); 137: 1293-307

Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmenthttp://www.ncbi.nlm.nih.gov/pubmed/19563760
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.http://www.ncbi.nlm.nih.gov/pubmed/18046415

Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P. and Kuriyan, J. 

Nature (2007); 450: 741-4

Differential modification of Ras proteins by ubiquitination http://www.ncbi.nlm.nih.gov/pubmed/16507365

Jura, N., Scotto-Lavino, E., Sobczyk, A., Bar-Sagi, D. 

Molecular Cell (2006); 21: 679-687

Mapping Cellular Routes of Ras – A Ubiquitin Trial. http://www.ncbi.nlm.nih.gov/pubmed/17172849

Jura, N., Bar-Sagi, D.

Cell Cycle (2006); 5: 2744-2747

A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogenhttp://www.ncbi.nlm.nih.gov/pubmed/17087933

Archer, H.*, Jura, N.*, Jacobson, M., Keller, J., Bar-Sagi, D. 

Gastroenterology (2006); 131: 1844-55  *) equal contribution

Chronic pancreatitis, pancreatic adenocarcinoma and the black box in betweenhttp://www.ncbi.nlm.nih.gov/pubmed/15686632

Jura, N., Archer, H., Bar-Sagi, D.

Cell Research (2005); 15: 72-77

An ex vivo model for functional studies of myofibroblastshttp://www.ncbi.nlm.nih.gov/pubmed/15723087

Kilarski, W., Jura, N., Gerwins, P.

Laboratory Investigation (2005); 85: 643-654

Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalishttp://www.ncbi.nlm.nih.gov/pubmed/15731048

Mezyk-Kopec, R., Bzowska, M., Potempa, J., Bzowska, M., Jura, N., Sroka, A., Black, R.A., Bereta, J.

Infection and Immunity (2005); 73: 1506-1514

Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cellshttp://www.ncbi.nlm.nih.gov/pubmed/15206946

Bzowska, M., Jura, N., Lassak, A., Black, R.A., Bereta, J.

European Journal of Biochemistry (2004); 271: 2808-2820

hSpry2 is targeted to the ubiquitin dependent proteasome pathway by c-Cblhttp://www.ncbi.nlm.nih.gov/pubmed/12593796

Hall, A.B.*, Jura, N.*, DaSilva, J., Jang, Y.J., Gong, D., Bar-Sagi, D.

Current Biology (2003); 13: 308-314. *) equal contribution.

Inactivation of Src family kinases inhibits angiogenesis in vivo: implications for a mechanism involving organization of the actin cytoskeletonhttp://www.ncbi.nlm.nih.gov/pubmed/14597409

Asymmetric dimer between two kinase domains of the EGF receptor. By Kate Engel.

Jura, N., Zhang, X, Endres, NF., Seeliger, M., Shindler, T., Kuriyan, J.

Molecular Cell (2011); 42: 9-22

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms
http://www.ncbi.nlm.nih.gov/pubmed/21474065

Littlefield, P. and Jura, N.

Proceedings of the National Academy of Sciences of the United States of America (2013);

110: 15169-15170

EGFR lung cancer mutants get specializedhttp://www.ncbi.nlm.nih.gov/pubmed/24023066

Fan Q.W., Cheng C. K., Gustafson W. C., Charron E., Zipper P., Wong R. A., Chen J., Lau J., Knobbe-Thomsen C., Weller M., Jura N., Reifenberger G., Shokat K. M., Weiss W. A.

Cancer Cell (2013); 24: 438-49

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in gliobalstomahttp://www.ncbi.nlm.nih.gov/pubmed/24135280
A robust methodology to subclassify pseudokinases based on their nucleotide binding properties.
Murphy J.M., Zhang Q., Young S.N., Reese M.L., Bailey F.P., Eyers P.A., Ungureanu D., Hammaren H., Silvennoinen O., Varghese L. N., Chen K., Tripaydonis A., Jura N., Fukuda K., Qin J., Nimchuk Z., Mudgett M. B., Elowe S., Gee C.L., Liu L., Daly R.J., Manning G., Babon J.J., Lucet I.S.
Biochem J (2014); 457: 323-34http://www.ncbi.nlm.nih.gov/pubmed/24107129
An ATP-competitive inhibitor modulates the allosteric function of the HER3 pseudokinase.
Littlefield P., Moasser M. M. and Jura N.
Chemistry & Biology (2014); 21: 453-8http://www.ncbi.nlm.nih.gov/pubmed/24135280
Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Littlefield P., Liu L., Mysore V., Shan Y., Shaw D.E. and Jura N.
Science Signaling (2014); 7, ra114http://www.ncbi.nlm.nih.gov/pubmed/25468994

Deposited Structures:            ,           ,            

4RIWhttp://www.rcsb.org/pdb/explore/explore.do?structureId=4RIW
4RIXhttp://www.rcsb.org/pdb/explore/explore.do?structureId=4RIX
4RIYhttp://www.rcsb.org/pdb/explore/explore.do?structureId=4riy

Deposited Structure:

4OTWhttp://www.rcsb.org/pdb/explore.do?structureId=4OTW

Deposited Structure:

3KEXhttp://www.rcsb.org/pdb/explore/explore.do?structureId=3kex

Deposited Structure:

3GT8http://www.rcsb.org/pdb/explore/explore.do?structureId=3GT8
In the news:


The Juxtamembrane Region of EGFR Takes Center Stage
Stevan R. Hubbard, Cell Preview (2009); 137: 1181-1183http://www.ncbi.nlm.nih.gov/pubmed/?term=19563749

Deposited Structures:           ,            ,

2RF9http://www.rcsb.org/pdb/explore/explore.do?structureId=2rf9
2RFDhttp://www.rcsb.org/pdb/explore/explore.do?structureId=2rfd
2RFEhttp://www.rcsb.org/pdb/explore/explore.do?structureId=2rfe
In the news:

Ras ubiquitination: Coupling spatial sorting and signal transmission
P. Rodriguez-Viciana, F. McCormick, Cancer Cell Preview (2006); 9: 243-244http://www.ncbi.nlm.nih.gov/pubmed/16616329

On the cover:

On the cover:

In the news:

Split personalities: the agonistic antagonist Sprouty
Gerhard Christofori, Nature Cell Biology News & Views (2003); 5: 377-379http://www.ncbi.nlm.nih.gov/pubmed/?term=12724768
Inducing Sprouty degradation
Nicole LeBrasseur, J. of Cell Biology Research Roundup (2003); 160: 804http://jcb.rupress.org/content/160/6/804.1.full?sid=a62e6cd9-a099-4c22-8dd3-2c00c16fab8b

Kilarski, W.W., Jura, N., Gerwins, P.

Experimental Cell Research (2003); 291: 70-82

In the news:


Genetically defined models of chronic pancreatitis
M. Schmid and D. C. Whitcomb
Gastroenterology Editorial (2006); 131: 2012-2015http://www.ncbi.nlm.nih.gov/pubmed/?term=schmid+whitcomb
Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor.
Kovacs E., Das R., Wang Q., Collier T.S., Cantor A., Huang Y., Wong K., Mirza A., Barros T., Grob P., Jura N., Bose R. and Kuriyan J
Molecular and Cellular Biology (2015); 35: 3083-102http://www.ncbi.nlm.nih.gov/pubmed/26124280

Deposited Structures:             ,            

5CNNhttp://www.rcsb.org/pdb/explore/explore.do?structureId=5CNN
5CNOhttp://www.rcsb.org/pdb/explore/explore.do?structureId=5CNO
Src defines a new pool of EGFR substrates.
Michael N. and Jura N.
Nature Structural and Molecular Biology (2015); 22: 945-7http://www.ncbi.nlm.nih.gov/pubmed/26643845
Structural basis for the non-catalytic functions of protein kinases.
Kung J.E.. and Jura N.
Structure (2016); 24: 7-24http://ac.els-cdn.com/S0969212615004591/1-s2.0-S0969212615004591-main.pdf?_tid=88d44bde-c12f-11e5-8300-00000aacb362&acdnat=1453484740_27da4ce7c5ffe0ac6a28200ff3eba2b1
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EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms. van Lengerich, B., Agnew, C., Puchner, E., Huang, B., and Jura N.
Proceedings of the National Academy of Sciences of the United States of America (2017) in presshttps://www.ncbi.nlm.nih.gov/pubmed/28320942