Kornberg Lab

Research in the Kornberg lab investigates cell-cell signaling processes that regulate and sculpt organogenesis and morphogenesis during development. We apply a variety of approaches, including classical and molecular genetics, and histological techniques ranging from fluorescence microscopy to fine structure analysis with the electron microscope. The systems we study include oogenesis, embryogenesis, and the development of various organs including airway, lung and various other epithelial tissues in Drosophila. Drosophila is ideal for these studies because of the many experimental tools with which this system is endowed and because of its usefulness as a model for understanding human development.

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Hedgehog signaling

Following on from our cloning of the Drosophila hedgehog (hh) gene (Tabata and Kornberg, 1992), our studies showed that the secreted Hh protein moves across segment borders in the embryo and across the Anterior/Posterior compartment border in the embryo and in the wing imaginal disc (Tabata and Kornberg, 1994)...

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Signal protein dispersion and constraint

Signaling proteins such as FGF, EGF, Hh, Dpp, and Wingless play vital roles during the induction, growth and patterning of tissues and organs in Drosophila. The mechanisms that move these signaling proteins, often over long distances, or that constrain them to signal only to their intended targets, have been investigated for many years; we have obtained strong evidence that movement and delivery is based direct cell-cell contact.

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Regulation and genetic control in the early embryo

For many animals, rapid divisions during the first stages of embryogenesis generate a population of undetermined cells that acquire developmental distinctiveness only as they prepare for gastrulation. These first stages have been thought to contribute little or no spatial information, and in animals such as amphibians, fish and insects, to rely entirely on maternal stores. In Drosophila, for example, the early divisions proceed with a cycle time of 9.6 min, and reportedly without gene expression. We discovered a small cohort of genes that is expressed at the early, pre-blastoderm stages.

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