Cardiovascular Research Intitute
Endothelial cell diversity in biology and disease
We seek to understand the diversification and maturation of vascular endothelium, its interaction and relationship with the hematopoietic system, and the implications for function and disease.
One example of specialized endothelial function with important clinical applications is hematopoietic stem cell (HSC) emergence from hemogenic vascular sites during development. We aim to investigate the programs that govern the hemogenic process, and whether those programs can be activated in mature endothelium for HSC production. In addition, we also investigate vascular regulation and hematopoiesis in the context of various clinical pathologies that include preeclampsia and HELLP syndrome, pediatric hemangioma, and vascular lung disorders.
Smith Cardiovascular Research Building, Room 310, 555 Mission Bay Blvd South, San Francisco, CA 94143-3120 PH: 415.514.1127