THE MINOR LAB Home of the Electrosome

Publications

2017

K2P2.1(TREK-1):activator complexes reveal a cryptic selectivity filter binding site. Lolicato, M., Arrigoni, C., Mori, T., Sekioka, Y., Bryant, C., Clark, K.A., Minor, D.L., Jr., Nature (2017)
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Stapled voltage-gated calcium channel (CaV) α-Interaction Domain (AID) peptides act as selective protein-protein interaction inhibitors of CaV Function. Findeisen, F., Campiglio, M., Jo, H., Abderemane-Ali, F., Rumpf, C.H., Pope, L., Rossen, N.D., Flucher, B.E., DeGrado, W.F., and Minor D.L., Jr., ACS Chemical Neuroscience  8 1313−1326 (2017)
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Two P domain potassium channels, introduction. Plant, L.D., Bayliss, D.A., Minor, D.L. Jr., Czirják, G., Enyedi, P., Lesage, F., Sepúlveda, F., Goldstein, S.A.N.  IUPHAR/BPS Guide to Pharmacology (2017) 
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2016

Unfolding of a temperature-sensitive domain controls voltage-gated channel activation. Arrigoni, C., Rohaim, A., Shaya, D., Findeisen ,F., Stein, R.A. Nurva, S.R., Mishra, S., Mchaourab, H.S., and Minor, D.L., Jr., Cell 164 922-936 (2016) PMID: 26919429 PMCID:PMC4769381
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Let it go and open up: An ensemble of ion channel active states. Minor, D.L., Jr., Cell 164 597-598 (2016)  PMID: 26871624
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2015

Insights into the molecular foundations of electrical excitation. Gaudet, R., Roux, B, and Minor, and D.L., Jr., Journal of Molecular Biology 427 1-2 (2015) PMID: 25542854
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Bacterial voltage-gated sodium channels (BacNaVs) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart. Payandeh, J. and Minor, D.L., Jr., Journal of Molecular Biology 427 3-30 (2015) PMID: 25158094 PMCID: PMC4277928
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2014

Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K2P channels. Lolicato, M., Riegelhaupt, P.M., Arrigoni, C., Clark, K.A., Minor, D.L., Jr., Neuron 84 1198-1212 (2014) PMID: 25500157 PMCID: PMC4270892
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Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries. Bagriantsev, S.N, Chatelain, F.C., Clark, K.A., Alagem, N., Reuveny, E., and Minor, D.L., Jr., ACS Chemical Neuroscience 5 812-822 (2014) PMID: 25028803 PMCID: PMC31476385
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Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels. Shaya, D., Findeisen, F., Abderemane-Ali, F., Arrigoni, C., Wong, S., Reddy Nurva, S., Loussouarn, G., and Minor, D.L., Jr. Journal of Molecular Biology 426 476-483 (2014) PMID: 24120938 PMCID: PMC3947372
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2013

Conduits of life's spark: A perspective on ion channel research since the birth of Neuron. Isacoff, E.Y., Jan, L.Y., and Minor, D.L., Jr., Neuron 80 658-674 (2013) PMID: 24183018 PMCIDPMC3867263
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Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain. Findeisen, F., Rumpf, C.H., and Minor, D.L., Jr., Journal of Molecular Biology 425 3217-3234 (2013) PMID: 23811053 PMCID: PMC3839849
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A high-throughput functional screen identifies small molecule regulators or temperature- and mechano-sensitive K2P channels. Bagriantsev, S. N., Ang, K.H., Gallardo-Godoy, A, Clark, K.A., Arkin, M.R., Renslo, A.R, and Minor, D.L., Jr., ACS Chemical Biology 8 1841-1851 (2013) PMID: 23738709PMCID: PMC3747594
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Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Tien, J., Lee, H.Y., Minor, D.L., Jr., Jan, Y.N, and Jan, L.Y., Proc. Natl. Acad. Sci. USA 110 6352-6357 (2013) PMID: 23576756 PMCID: PMC3631655
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Patch-clamp characterization of the MscS-like mechanosensitive channel from Silicibacter pomeroyi. Petrov, E., Palanivelu, D., Nomura, T., Constantine, M., Rohde, P.R., Cox, C.D., Minor, D.L., Jr., and Martinac, B., Biophysical Journal 104 1426-1434 (2013) PMID: 23561519 PMCID: PMC3617418
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Using yeast to study potassium channel function and interactions with small molecules. Bagriantsev, S. and Minor, D.L., Jr., Methods in Molecular Biology 995 31-42 (2013) PMID: 23494370 PMCID: PMC3950311
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Structure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M-current modulation. Xu, Q., Chang, A., Tolia, A., and Minor, D.L., Jr., Journal of Molecular Biology 425 378-394 (2013) PMID: 23178170 PMCID:PMC3540129
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2012

Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains. Bagriantsev, S., Clark, K.A., and Minor, D.L., Jr., The EMBO Journal 31 3297-3308 (2012) PMID: 22728824 PMCID: PMC3411076
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A glutamate switch controls voltage-sensitive phosphatase function. Liu L., Kohout, S.C., Xu, Q., Müller, S., Kimberlin, C.R., Isacoff, E.Y. Minor, D.L., Jr., Nature Structural and Molecular Biology 19 633-641 (2012) PMID: 22562138 PMCID: PMC3529583
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Chemical informatics and target identification in a zebrafish phenotypic screen. Laggner, C., Kokel, D., Setola, V., Tolia, A., Lin, H., Irwin, J.J., Keiser, M.J., Minor, D.L., Jr., Roth, B.L., Peterson, R.T., Shoichet, B.K., Nature Chemical Biology 8 144-146 (2012) PMID:22179068 PMCID: PMC3262069
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2011

Multiple modalities converge on a common gate to control K2P channel function. Sviatoslav N Bagriantsev, Remi Peyronnet, Kimberly A Clark, Eric Honore, Daniel L Minor Jr., The EMBO Journal 30, 3594–3606 (2011)
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Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. David Shaya, Mohamed Kreir, Rebecca A. Robbins, Stephanie Wong, Justus Hammon, Andrea Brüggemann, and Daniel L. Minor, Jr., PNAS Proc Natl Acad Sci USA Jul 26;108(30):12313-8. (2011)
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Calmodulin overexpression does not alter CaV1.2 function or oligomerization state. Felix Findeisen, Alexandra Tolia, Ryan Arant, Eun Young Kim, Ehud Y. Isacoff and Daniel L. Minor, Jr., Channels 5:4, 320-324; (2011)
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2010

Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation. Findeisen, Felix, Minor, Jr., D.L., Channels 4, 28-43 (2010)
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Structural Basis for the Differential Effects of CaBP1 and Calmodulin on CaV1.2 Calcium-Dependent Inactivation. Findeisen, F., Minor, Jr., D.L., Structure 18, 1617–1631 (2010)
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Multiple C-terminal tail Ca2+/CaMs regulate CaV1.2 function but do not mediate channel dimerization. Ki., E., Rumpf, C., Van Petegem, F., Arant, R.J., Findeisen, F., Cooley, E., Isacoff, E., Minor, Jr., D.L., The EMBO Journal 29, 3924-3938 (2010)
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Small molecule-ion channel match making: A natural fit for new ASIC ligands. Bagriantsev, S. and Minor, D.L., Jr., Neuron 68 1-3 (2010)

Calmodulin interactions with CaV1 and CaV2 voltage-gated calcium channel IQ domains. Kim, E., Findeisen, F., Minor, Jr., D.L. Handbook of Metalloproteins (2010)
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Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Kohout, S., Bell, S.C., Liu, L., Xu, Q., Minor, Jr., D.L., Isacoff, E.Y, Nature Chemical Biology 6, 369-375 (2010)
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2009

An Overview of Ion Channel Structure. Published in the Handbook of Cell Signaling, 2nd Edition, Chapter author: Daniel L. Minor, Pages 201-208, Copyright Elsevier (2009)
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Selection of Inhibitor-Resistant Viral Potassium Channels Identifies a Selectivity Filter Site that Affects Barium and Amantadine Block. Chatelain, F.C., Gazzarrini, S., Fujiwara, Y., Arrigoni, C., Domigan, C., Ferrara, G., Pantoja, C., Thiel, G., Moroni, A., Minor, Jr., D.L., PLoS ONE Vol 4 Issue 10 e7496 (2009)
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Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function. Minor, Jr., D.L., Molecular BioSystems, 5, 802–810 (2009)
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Crystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Xu, Q., Minor, Jr., D.L., Protein Science 18:2100—2114 (2009)
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Disruption of the IS6-AID Linker Affects Voltage-gated Calcium Channel Inactivation and Facilitation. Findeisen, F., Minor, Jr., D.L.,The Journal of General Physiology 133 No. 3, 327-343 (2009)
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A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms. Hammon, J., Palanivelu, D.V., Chen, J., Patel, C., Minor, Jr., D.L. Protein Science 18, 121-133 (2009)
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2008

Transmembrane domain length of viral K channels is a signal for mitochondria targeting. Balss, J., Papatheodorou, P., Mehmel, M., Baumeister, D., Hertel, B., Delaroque, N., Chatelain, F.C., Minor, Jr., D.L., Van Etten, J.L., Rassow, J., Moroni, A., Thiel, G., PNAS 34, 12313-12318 (2008)
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X-ray Crystal Structure of a TRPM Assembly Domain Reveals an Antiparallel Four-stranded Coiled-coil. Fujiwara, Y., Minor, Jr., D.L., J. Mol. Biol. 383, 854-870 (2008).
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Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Kim, E.Y., Rumpf, C.H., Fujiwara, Y., Cooley, E.S., Van Petegem, F., and Minor, Jr., D.L., Structure 16, 1455-1467 (2008).
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Alanine-Scanning Mutagenesis Defines a Conserved Energetic Hotspot in the CaVα1 AID-CaVβ Interaction Site that Is Critical for Channel Modulation. Petegem, F.V., Duderstadt, K.E., Clark, K.A., Wang, M., Minor, Jr., D.L., Structure 16, 280-294 (2008)
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2007

Puzzle plugged by pore plasticity. Minor, Jr., D.L., Molecular Cell 26 459-460 (2007)
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The neurobiologist's guide to structural biology: A Primer on why macromolecular structure matters and how to evaluate macromolecular structural data. Minor, Jr., D.L., Neuron 54 511-533 (2007)
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Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Howard, R.J., Clark, K.A., Holton, J.M., and Minor, Jr., D.L., Neuron 53 663-675 (2007)
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2006

A multimeric membrane protein reveals 14-3-3 isoform specificity in forward transport in yeast. Michelsen, K., Mrowiec, T., Duderstadt, K.E., Frey, S., Minor, Jr., D.L., Mayer, M.P., Schwappach, B., Traffic 7 903-916 (2006)
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Coiled-coils direct assembly of a cold-activated TRP channel. Tsuruda, P., Julius, D., and Minor, Jr., D.L., Neuron 51 201-212 (2006)
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Three-dimensional structure of the KChIP/Kv4.3 T1 domain complex reveals a cross-shaped octamer. Pioletti, M., Findeisen, F., Hura, G.L., and Minor, Jr., D.L., Nature Structural & Molecular Biology (2006)
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A sensitive channel family replete with sense and motion. Minor, Jr., D.L., Nature Structural & Molecular Biology 13 388-390 (2006)
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Wanting contact: how to pick up a channel. Minor, Jr., D.L., Nature Chemical Biology 2 298-299 (2006)
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The structural biology of voltage-gated calcium channel function and regulation. Van Petegem, F. and Minor, Jr., D.L., Biochemical Society Transactions Vol 34, part 5 (2006)
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2005

Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Van Petegem, F., Chatelain, F.C., and Minor, Jr., D.L., Nature Structural and Molecular Biology 12 1108-1115 (2005)
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The pore helix dipole has a minor role in inward rectifier channel function. Chatelain, F.C., Alagem, N., Xu, Q., Pancaroglu, R., Reuveny, E., and Minor, Jr., D.L., Neuron 47, 833-843 (2005)
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Bend to open? Minor, Jr., D.L., Structure 13 1094-1095 (2005)
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2000-2004

Overview: Function and three-dimensional structures of ion channels. Minor, Jr., D.L., Handbook of Cellular Signaling, Eds. R. Bradshaw and E. Dennis, Academic Press, San Diego (2004)
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Structure of a complex between a voltage gated calcium channel beta-subunit and an alpha-subunit domain. Van Petegem, F., Clark, K.A., Chatelain, F.C., and Minor, Jr., D.L., Nature 429 671-675 (2004)
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The structure of APPBP-1UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Walden, H., Podgorski, M.S., Huang, D.T., Miller, D.W., Howard, R.J., Minor, Jr., D.L., Holton, J.M., and Schulman, B.A., Molecular Cell 12 1427-1437 (2003)
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Consensus-derived structural determinants of the ankyrin repeat motif. Mosavi, L. K., Minor, Jr., D.L., and Peng, Z.-y., Proceedings of the National Academy of Sciences USA 99 16029-16034 (2002)
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Potassium Channels: life in the post-structural world. Minor, Jr., D.L., Current Opinion in Structural Biology 11 408-414 (2001)
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Controlling potassium channel activities: Interplay between the membrane and intracellular factors. Yi, B.A, Minor, Jr., D.L., Lin, Y.F., Jan, Y.N. and Jan, L.Y., Proceedings of the National Academy of Sciences USA 98 11016-11023 (2001)
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The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Minor, Jr., D.L., Lin, Y.F, Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y. and Berger, J.M., Cell 102 657-670 (2000)
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1994-1999

Transmembrane structure of an inwardly rectifying potassium channel. Minor, Jr., D.L., Masseling, S.J., Jan, Y.N. and Jan, L.Y., Cell 96 879-891 (1999)
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Identification of (D)-peptide ligands through Mirror-Image phage display. Schumacher, T.N.M., Mayr, L.M., Minor, Jr., D.L., Milhollen, M.A., Burgess, M.W. and Kim, P.S., Science 271 1854-1857 (1996)
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Context-dependent secondary structure formation of a designed protein sequence. Minor, Jr., D.L. and Kim P.S., Nature 380 730-734 (1996)
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Measurement of the beta-sheet forming propensities of amino acids. Minor, Jr., D.L., and Kim P. S., Nature 367 660-663 (1994)
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Context is a major determinant of beta-sheet propensity. Minor, Jr., D.L. and Kim P.S., Nature 371 264-267 (1994)
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