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Structure of Human K2P4.1
 

PDB ID: G124I: 4RUE, W262S: 4RUF

Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K2P channels. Lolicato, M., Riegelhaupt, P.M., Arrigoni, C., Clark, K.A., Minor, D.L., Jr. Neuron 84 1198-1212 (2014) PMID: 25500157 PMCID: PMC4270892

 

 
Structure of NaVAe1p (Alkalilimnicola ehrlichii)
 

PDB ID: 4LTO, 4LTP, 4LTQ, and 4LTR

Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels. Shaya, D., Findeisen, F., Abderemane-Ali, F., Arrigoni, C., Wong, S., Reddy Nurva, S., Loussouarn, G., and Minor, D.L., Jr. Journal of Molecular Biology 426 476-483 (2014) PMID: 24120938 PMCID: PMC3947372
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Crystal structure of Ciona intestinalis voltage sensor-containing phosphatase
 

PDB ID: 3V0D, 3V0E, 3V0F, 3V0G, 3V0H, 3V0I, 3V0J

A glutamate switch controls voltage-sensitive phosphatase function. Liu L., Kohout, S.C., Xu, Q., Müller, S., Kimberlin, C.R., Isacoff, E.Y. Minor, D.L., Jr., Nature Structural and Molecular Biology 19 633-641 (2012) PMID: 22562138 PMCID: PMC3529583

 
Ca2+/CaM:KV7.4 (KCNQ4) B-helix complex
 

PDB ID: 4GOW

Structure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M-current modulation. Xu, Q., Chang, A., Tolia, A., and Minor, D.L., Jr., Journal of Molecular Biology 425 378-394 (2013)  PMID: 23178170 PMCID:PMC3540129 

 
Ca2+/CaM-CaV1.2 PreIQ-IQ domain complex
 

PDB ID: 3OXQ

Multiple C-terminal tail Ca2+/CaMs regulate CaV1.2 function but do not mediate channel dimerization. Ki., E., Rumpf, C., Van Petegem, F., Arant, R.J., Findeisen, F., Cooley, E., Isacoff, E., Minor, Jr., D.L. The EMBO Journal, 29, 3924-3938 (2010)

 
CaBP1
 

PDB ID: 3OX5

Structural Basis for the Differential Effects of CaBP1 and Calmodulin on CaV1.2 Calcium-Dependent Inactivation. Findeisen, F., Minor, Jr., D.L. Structure 18, 1617–1631 (2010)

 
CaBP1 K130A
 

PDB ID: 3OX6

Structural Basis for the Differential Effects of CaBP1 and Calmodulin on CaV1.2 Calcium-Dependent Inactivation. Findeisen, F., Minor, Jr., D.L. Structure 18, 1617–1631 (2010)

 
A trimeric form of the Kv7.1 A domain Tail
 

PDB ID: 3HFE and 3HFC

Xu, Q., Minor, Jr., D.L., Crystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Protein Science 18:2100—2114 (2009)

 
TRPM7 Assembly Domain
 

PDB ID: 3E7K

Fujiwara, Y., Minor, Jr., D.L. X-ray Crystal Structure of a TRPM Assembly Domain Reveals an Antiparallel Four-stranded Coiled-coil. J. Mol. Biol. 383, 854-870 (2008).

 

 

 
CaV 2.1 IQ domain-Ca2+/Calmodulin Complex
 

PDB ID: 3DVM

Kim, E.Y., Rumpf, C.H., Fujiwara, Y., Cooley, E.S., Van Petegem, F., and Minor, Jr., D.L. Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure 16, 1455-1467 (2008).

 

 

 
CaV 2.2 IQ domain-Ca2+/Calmodulin Complex
 

PDB ID: 3DVE, 3DVJ

Kim, E.Y., Rumpf, C.H., Fujiwara, Y., Cooley, E.S., Van Petegem, F., and Minor, Jr., D.L. Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure 16, 1455-1467 (2008).

 

 

 
CaV 2.3 IQ domain-Ca2+/Calmodulin Complex
 

PDB ID: 3DVK

Kim, E.Y., Rumpf, C.H., Fujiwara, Y., Cooley, E.S., Van Petegem, F., and Minor, Jr., D.L. Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation. Structure 16, 1455-1467 (2008).

 

 

 
Kv7.4 (KCNQ4) assembly specificity domain
 

2OVC Kv7.4 (KCNQ4) assembly specificity domain
PDB ID: 2OVC

Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Howard, R.J., Clark, K.A., Holton, J.M., and Minor, Jr., D.L., Neuron 53 663-675 (2007)

 

 
KChIP1/Kv4.3 T1 domain complex
 

2I2R KChIP1/Kv4.3 T1 Domain complex
PDB ID: 212R

Three-dimensional structure of the KChIP/Kv4.3 T1 domain complex reveals a cross-shaped octamer. Pioletti, M., Findeisen, F., Hura, G.L., and Minor, Jr., D.L., Nature Structural & Molecular Biology 13 987 995 (2006)

 

 
Voltage-gated Potassium Channel T1 assembly domain
 

1QDW Kv1.2 T1 domain 33-119
PDB ID: 1QDW

1QDV Kv1.2 T1 domain 33-131
PDB ID: 1QDV

1DSX KV1.2 T1 domain33-131 T46V mutant
PDB ID: 1DSX

The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Minor, Jr., D.L., Lin, Y.F, Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y. and Berger, J.M. Cell 102 657-670 (2000)

 

 
Voltage-gated Calcium Channel β-subunit
 

1T0H CaVβ2a
PDB ID: 1TOH

1T0J CaVβ2a - CaV1.2 AID complex
PDB ID: 1TOJ

Structure of a complex between a voltage gated calcium channel beta-subunit and an alpha-subunit domain.
Van Petegem, F., Clark, K.A., Chatelain, F.C., and Minor, Jr., D.L. Nature 429 671-675 (2004)

 
CaV1.2 IQ domain-Ca2+/Calmodulin Complex
 

2BE6 CaV1.2 IQ domain-Ca2+/CaM complex
PDB ID: 2BE6

Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Van Petegem, F, Chatelain, F.C., Minor, Jr., D.L., Nature Structural & Molecular Biology 12 1108-1115 (2005)

 
 
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